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In addition to its role in oxidizing macromolecules such as proteins and lipids, H 2 O 2 has also been proposed to function as a signal to induce the expression of genes involved in the senescence process ( Arabidopsis could be induced by ozone (Miller et al., 1999) and the expression of many other SAGs were also induced by ROS (Navabpour et al., 2003), indicating that ROS might function as a signal to promote senescence

Endocrinology (1962) 70:26771

However, conflicting results have also been reported

Farhat Z, Browne RW, Bonner MR, Tian L, Deng F, Swanson M, Mu L

In this study, the average time period after diagnosis to the start of the trial was 6.4 years