In the last few years, various GSH modulation-enhanced combinational therapy strategies have been extensively exploited, accompanied by the development of versatile metal-based nanosystems with different structures, functionalities, and treatment performances ( In view of the rapid development of GSH-responsive and -exhausting metal nanomedicines in potentiating cancer therapy, we summarize and outline the recent advancements, mechanisms, prospects, and challenges in this field from different strategies (Scheme 1)
Then 80% of the supernatant was transferred to a different tube and dried down using a nitrogen evaporator
Translation into people cannot be assumed
While these drugs remain covered for conditions such as Type 2 diabetes or cardiovascular disease, many Californians who relied on them for obesity treatment are now facing out-of-pocket costs or discontinuation altogether
Preclinical studies showed that indeed, the Nottingham group was on the right track
Secondly, we combined data from trials that varied in duration, baseline characteristics, and types of AOMs, which might result in heterogeneity to the meta-analysis, so we used a random-effects model for statistical analysis