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The notion that astrocyte reactivity is somehow globally harmful per se and should therefore be blocked in its entirety is likely to do more harm than good and is no longer tenable

Neonatal blood concentrations of metformin have been found to equal or surpass half of maternal levels, raising concerns about the potential impact of elevated metformin levels on neonatal glucose metabolism and the development of hypoglycemia in newborns

Systemic absorption for muscle tissue remains lower when taking capsules compared to direct injections

Eating smaller meals more slowly may help reduce stomach irritation

Side effects experienced (type, severity, timing)