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This means large-scale clinical trials in humans to prove safety, efficacy, and consistent dosing

Rybelsus works by mimicking the action of the naturally occurring hormone GLP-1, which stimulates insulin secretion in response to food intake, suppresses glucagon release (a hormone that raises blood sugar), and slows gastric emptying

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Jacques et al, 1996), and an interaction between vitamin B 6 deficiency and heterozygous CBS defects might be expected

Fortunately, this potential side effect seems to be linked specifically to the largest doses of the drug, and all three people began to regain their zest for life after reducing their dosage

Vijay S, Patterson A, Olpin S, Henderson MJ, Clark S, Day C, et al