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As a note, the common side effects of excess vitamin intake include flushing, diarrhea, nausea, and vomiting
Benedict C, Frey WH 2nd, Schioth HB, Schultes B, Born J, Hallschmid M
For people with inflammatory arthritis (e.g, Rheumatoid arthritis, Psoriatic Arthritis, Lupus), this risk is even higher because they experience more heart disease complications than the general population
Standard 3mL medical syringes have 0.2mL increments, creating 1000-microgram dose variation completely unacceptable for research protocols where target doses range from 100-500 micrograms
org/10.1016/j.clnesp.2020.03.008 Traina, G