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Functional factors with a nutritional basis operate predominantly through energy metabolism optimization, calcium homeostasis maintenance, and regulation of protein synthesis, whereas functional factors derived from natural extracts exert their effects more through multitarget synergistic mechanisms, including antioxidant and anti-inflammatory action, immune enhancement, gut microbiota regulation, and muscle fiber type transformation

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Morris: Patients receive a total of six doses of Xofigo (radium-223) and no more than ten doses of chemotherapy