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In addition to its role in energy metabolism, creatine appears to act as a buffer against the harmful effects of reactive oxygen species in cardiovascular tissues, potentially slowing the progression of cardiovascular disease [110], although this is a topic that deserves further investigation as not all evidence shows benefits of higher intracellular levels of creatine [111]
Retatrutide has not been specifically studied for kidney outcomes
doi: 10.3390/ijerph17103664 48 BornsteinSRRubinoFKhuntiKMingroneGHopkinsDBirkenfeldALet al
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Lancet 398 , 262276 (2021)
risks, including the consequences of further loss of lean mass, especially in frail, sarcopenic patients
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