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The enzymes tryptophan-2,3-dioxygenase or indoleamine 2,3-dioxygenase 1 and 2 (IDO1 and IDO2) catalyze the degradation of tryptophan to N-formylkynurenine, which is a key step of the kynurenine pathway, followed by subsequent conversion of N-formylkynurenine to kynurenine, 3-hydroxykynurenine, quinolinic acid and picolinic acid [269]

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Mice were subjected to single i.p

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