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Common symptoms include: Extreme fatigue that is not relieved by rest Post-exertional malaise: worsening of symptoms after physical or mental activity Sleep problems: unrefreshing sleep, insomnia, or other sleep disturbances Cognitive difficulties: problems with memory, focus, and concentration (often referred to as "brain fog") Muscle or joint pain Headaches Sore throat Tender lymph nodes Dizziness that worsens with moving from lying down or sitting to standing Causes and Risk Factors The exact cause of CFS is unknown, but it is believed to result from a combination of factors: Genetics: A family history of CFS or other autoimmune diseases can increase the risk

doi:10.1093/BMB/LDR030 6

Damaged mitochondria are not removed in time and accumulate to form waste mitochondria, which release more ROS, accelerating muscle atrophy ( 2.3 Lipid peroxidation-induced muscle cell death and atrophy Lipid peroxidation is a byproduct of cellular responses to oxidative stress

The mitochondrial protein FDX1 has been validated as a target of the anticancer drug Elesclomol, which induces specific copper-mediated cell death by facilitating copper ion delivery [99]

Science 254: 16471651

No finalized large-scale human clinical trials are published that demonstrate safety and efficacy in humans