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Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimers disease

This is primarily achieved through chelation therapy, which utilizes agents to bind and excrete iron, thereby preventing iron-induced organ damage

Exercise can increase dendritic spine density by regulating the turnover process of dendritic spines (including their generation, elimination, and rate)

A 2025 pilot study published in PubMed confirmed short-term tolerance in 2 participants at 20mg intravenously, though the sample size remains too limited for definitive safety conclusions

MDPI 9 (12), 1111

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