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Cellular and molecular control of lipid metabolism in idiopathic pulmonary fibrosis: clinical application of the lysophosphatidic acid pathway

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However, 3 enzymes involved in the last steps of the de novo pathway, namely kynurenine 3-monooxygenase (KMO), 3-hydroxyanthranilate 3,4-dioxygenase (HAAO), and the rate limiting nicotinate-nucleotide pyrophosphorylase (QPRT) were upregulated in the kidneys of cKOt mice (Figure 4 and Supplemental Figure 3)

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