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No affiliation with Eli Lilly and Company, the only US source of FDA-approved tirzepatide

Drugs 86 , 1136 (2026)

They may be prescribed when a patients needs cannot be met by a commercially available drug or during shortages

Whats happening with accelerated weight loss is that fat is shrinking too fast, and theres not enough time, even though you have elasticity in your skin, for it to catch up. That is why someone on a GLP-1 may feel like they suddenly look tired, hollow, or less lifted, even if they feel healthier overall

Currently, common clinical GLP-1RAs include exenatide and exenatide-LAR [34,35,36,37,38,39,40], lixisenatide [41,42,43,44], beinaglutide [45], liraglutide [46,47,48,49,50,51,52,53], semaglutide [54,55,56,57,58], albiglutide [59,60,61], dulaglutide [62,63,64], oral semaglutide [58, 65,66,67], PEG-loxenatide [68] and tirzepatide [68,69,70,71,72,73] (Table 1)

Integrate a medically supervised weight management program into your existing practice or launch a standalone clinic