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Moreover, further investigation concerning the influence of ITC and Se on factors affecting the complete epigenetic setting of the transformed cell, including DNA methylation, chromatin remodelling factors, histone modifications and CpG-binding proteins seems warranted in order to decipher their impact on DNA methylation patterns in cancer development

Most human studies used intravenous administration

This hydrolysis was attributed to putative esterases and activity was confirmed for both culture supernatants as well as whole cells, however, the extracellular enzymes proved to be unstable

Organ-specific protection mediated by cooperation between vascular and epithelial barriers

doi:10.1038/srep14468 197

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