Exelixis drops tissue factor-targeting ADC after deciding its no match for Tivdak , (2024)
Metabolism of polyamines and kidney disease: a promising therapeutic target
Abdelmalek, J
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For instance, research shows MOTS-c drives glucose into the pentose phosphate pathway (for anabolic needs and antioxidant defense) rather than burning it immediately via glycolysis, while simultaneously increasing fatty-acid oxidation by upregulating carnitine shuttle activity in mitochondria
Anti-Inflammatory and Antioxidant Effects: Investigate suppression of pro-inflammatory cytokines (e.g., IL-6, TNF-) and enhancement of superoxide dismutase (SOD) and other antioxidant pathways