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doi: 10.3389/fendo.2021.814770 Received 14 November 2021 Accepted 13 December 2021 Published 10 January 2022 Volume 12 - 2021 Edited by Cristina Giaroni, University of Insubria, Italy Reviewed by Eliana Piantanida, University of Insubria, Italy

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In the Walsh framework, toxic overload is one biochemical pattern that may coexist with undermethylation, copper imbalance, pyroluria or other contributors

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Participants self-reported their ethnic backgrounds into categories such as White, Mixed, Asian or Asian British, Black or Black British, and Other ethnic groups, with the majority (~94%) identifying as White British

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