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Notably, the cytoplasmic C-terminal tail of ZnT1 alone can inhibit the channel, suggesting that the inhibition of L-type calcium channels by ZnT1 is independent of zinc channel function

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There is some evidence to suggest that patients receiving methotrexate, commonly used in rheumatoid arthritis, are at increased risk of nonmelanoma skin cancer, possibly due to the photosensitizing nature of methotrexate

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