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Patients with even mid-range to high-range levels of vitamin B12 often still have a high MCV and high homocysteine (discussed below) and can benefit from vitamin B12 levels

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112 Overactivity of the HPA axis may be caused by damaged astrocytes and aberrant GR function

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A key concept for understanding this interface is that while health-damaging behaviors (e.g.: poor diet, excessive alcohol consumption, sleep deprivation and circadian disruption) contribute to allostatic load and the many consequences of such behaviors on triggering and exacerbating these illnesses, it is increasingly recognized that health-promoting behaviors that protect mitochondrial metabolism and energy regulation are an essential component of successful allostasis