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We examine the role of receptor binding kinetics and -arrestin-biased signaling in the observed trafficking profiles, identifying a linked set of agonist characteristics optimally suited for insulin secretion, not shared by GLP-1R agonists in the current clinical use

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Statins were also found to decrease the expression of some selenoproteins, including GPx1 [170, 171] due to their effects on the biosynthesis of isopentyl pyrophosphate