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Also, as this is a non-invasive method, there is no sudden increase in blood levels

To some extent, both GSH precursors as well as GSH itself can be effective

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They absorb differently, they are dosed differently, and they suit different patients for different reasons

COMT normally converts: Levodopa 3-O-methyldopa (3-OMD) Dopamine metabolism also increases Tolcapone blocks COMT Increases levodopa levels in blood Increases levodopa delivery to brain Prolongs levodopa duration of action Reduces wearing-off symptoms Reduces motor fluctuations Special Point: Tolcapone inhibits COMT both in peripheral tissues and in the CNS, unlike entacapone (mostly peripheral)