glp 1 alcoholism GLP-1s tied to lower alcohol intake for adults with overweight, obesity The Role of Glucagon-Like Peptide-1

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Peripheral GLP-1/GLP-1RAs may also interact with the CNS indirectly by GLP-1R expressed on vagal afferent fibers, signaling via nodose ganglia (57) to the nucleus tractus solitarii within the brainstem

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However, this is unlikely to reflect the physiological situation under which the central GLP1 system evolved, and thus, it will be important to determine whether PPG neurons are indeed only a secondary satiation system under more naturalistic feeding conditions in rodents and humans