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doi: 10.1016/s1097-2765(00)80425-6 15 PhilpottCCJadhavS

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Symptoms include spreading redness and growing warmth around the site, pus or drainage, and fever typically appearing within 2448 hours after the infusion

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Owing to diverse TME including as perfusion, oxygenation, vascular irregularities, and other metabolic conditions, such stimuli-responsive systems are specially developed for anti-cancer medication [299]