Kinne RK, Castaneda F
Food and Drug Administration National Institute of Diabetes and Digestive and Kidney Diseases American Diabetes Association National Institutes of Health World Health Organization This article is for general information only and is not a substitute for professional medical advice

You should contact your GP or diabetes care team if: Cold sensitivity is severe, persistent, or progressively worsening You experience cold intolerance accompanied by other symptoms such as extreme fatigue, constipation, dry skin, hair loss, or unexplained weight gain You develop symptoms suggestive of hypothyroidism (underactive thyroid), which can cause cold sensitivity (note that while GLP-1 receptor agonists have been associated with C-cell tumours in rodent studies, there is no established link to hypothyroidism in humans) You notice signs of anaemia, such as pallor, breathlessness, or palpitations, which can cause cold sensitivity Cold hands or feet are accompanied by colour changes (white, blue, or red), pain, or numbness, which may indicate circulatory problems You experience unexplained fever, chills, or rigors, which could suggest infection You have symptoms of hypoglycaemia (low blood sugar) such as shakiness, sweating, or confusion, especially if you also take insulin or sulfonylureas NICE guidance (NG28) recommends regular monitoring of patients on GLP-1 receptor agonists, including assessment of glycaemic control, weight, and tolerability

Another study focusing on liraglutide users reported that 85.6% of participants lost more than 4.4 lbs (2 kg) within 50 days, with an average loss of 10.8 lbs (4.9 kg)
There are B12 pills that can add B12 to the body, but they also rely on the bodys ability to extract nutrients
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