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Race-specific differences in antioxidant enzyme activity in patients with type 2 diabetes: a potential association with the risk of developing nephropathy

31,32 Impaired flow in the cerebral microcirculation due to an increase in blood viscosity may lead to stasis of blood in these vessels, which causes ischaemic tissue damage

Short-chain fatty acids (SFCAs) like acetate, butyrate and propionate, derived from host microbial fermentation of non-digestible carbohydrates, transduce signals through GPCR to promote anti-inflammatory cytokines (IL-10, IL-18) and Treg responses [198, 199] These SCFAs also suppress pro-inflammatory histone deacetylase (HDAC), NF-B and nitric oxide production, thus diminishing oxidative stress-induced epithelial cell apoptosis, and exerting a protective effect on colonic and cardiac health [199]