surpass trial tirzepatide Read now: The SURPASS-EARLY found that starting #tirzepatide early in #type2diabetes led to greater improvements in blood sugar, body weight, and waist size than intensified standard care. https://bit.ly/3RWnB8m Efficacy and safety of tirzepatide

Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors: role of alpha4 and alpha7 receptors in neuroprotection

The goal is to accumulate that ~150 minutes a week at moderate effort (where you can talk but not sing during the activity), or 75 minutes a week if doing vigorous effort (where talking is difficult)

A study developed a lipopolysaccharide (LPS) induced ICmodel in mice

There was even a theory originally put out in the 1950s called The Free Radical Theory of Aging* which basically held that we age by rusting from within, due largely (but not exclusively) to free radical damage

Through a judicious selection of clear fluids, individuals can navigate the nuanced terrain of hydration while advancing towards their weight loss goals with confidence

6.8% on placebo in STEP 1 Most common timing / during the first 8 to 20 weeks of dose escalation Discontinuation rate due to GI events / approximately 4.5% in key trials Mechanism / delayed gastric emptying plus direct brainstem GLP-1 receptor activation Red-flag sign / inability to keep fluids down for more than 24 hours Emergency sign / hematemesis (bloody vomit), severe epigastric pain, or signs of pancreatitis Dose modification / your prescriber may hold or reduce the dose rather than discontinue Dehydration risk / higher in patients also taking SGLT2 inhibitors or diuretics Why Wegovy Causes Vomiting Semaglutide 2.4 mg triggers vomiting through two overlapping pathways: slowed gastric motility and direct central nervous system signaling