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In a mouse model of T1DM, short-term treatment with D-Ala 2 -GIP prevented a decrease in bone formation parameters (collagen maturation index) and improved mechanical properties at the tissue level (Mansur et al., 2015)

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515 Preliminary data have shown that the pharmacological effects of IGF-1 affect synaptic development primarily by modulating the MAPK and mTOR pathways, as validated in PhelanMcDermid syndrome and Rett syndrome

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