Metz, T
Biomeditsinskaia Khimiia
In vitro co-immunoprecipitation and fluorescence polarisation assays have investigated the binding affinity of Proxofim for the p53 interaction domain, examining whether the DRI construct competitively displaces endogenous FOXO4 from the FOXO4-p53 complex in senescent fibroblast cultures
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Excretion and clearance As a small peptide (15 amino acids, approximately 1419 Da), BPC-157 is likely cleared primarily through proteolytic degradation and subsequent clearance of amino acids and small fragments, rather than significant excretion of intact peptide
