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In 2024, these medications became even more accessible and effective, with studies showing: Significant Weight Loss : Many individuals lost up to 15% or more of their body weight

Targeted Micronutrients Micronutrient adequacy is another key consideration

References for the retatrutide data: Jastreboff et al., NEJM 2023: Sanyal et al., Nature Medicine 2024: Giblin et al., TRIUMPH rationale, Diabetes Obesity Metabolism 2025: How to Minimize Side Effects and Maximize Comfort GLP-1s can cause nausea, constipation, and appetite suppression

Perimenopause, the stage before menopause, can last for several years

Sesame founder and president Michael Botta, M.D., said the FDA declaration won't have an impact on Sesame's business

The biggest difference is that medication can override intense hunger and cravings driven by biology