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Two similar and weakly defined subspecies occur in North Carolina the green frog (Rana clamitans melanota) in the Mountains, Piedmont and northern Coastal Plain and the bronze frog (Rana clamitans clamitans) in the southeastern Coastal Plain

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However, this interaction was not required for small molecule agonist TT-OAD2 that elicited cAMP signaling without the presence of an ECD 14

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