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The category itself is not new
It reduces oxidative stress, downregulates high mobility group box-1/ toll-like receptor 5 (HMGB1/TLR5) signaling, and preserves mitochondrial integrity, ultimately inhibiting apoptosis
Most are once-daily or once-weekly injections
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This study demonstrates physiological effects of endogenous nitrate in the modulation of cardiovascular function
1.2 Mechanisms of uric acid metabolism Purine sources within the human body are distinguished into endogenous and exogenous categories, with 80% originating from endogenous synthesis or the oxidative breakdown of nucleic acids
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