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Results From the bibliographic search, 78 articles were related to the select descriptors, but only 15 articles met all inclusion criteria (Figure 1)

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-Dosages in infants and children are initiated at 50 mg and gradually increased based on therapeutic sufficiency and tolerability -Sugar-free oral solution can be administered alone or mixed in other beverages or liquid food

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309,310 Dysregulation of pulmonary microbiome ecology or destruction of the gut-lung axis can lead to DNA damage, induce genomic instability, and alter host susceptibility to carcinogenic damage, resulting in lung cancer development

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