doi: 10.3389/fgene.2020.566244 Received 16 July 2020 Accepted 07 September 2020 Published 02 October 2020 Volume 11 - 2020 Edited by Giovanni Cenci, Sapienza University of Rome, Italy Reviewed by Daniel Vaiman, Institut National de la Sant et de la Recherche Mdicale (INSERM), France
Nestin and SOX2 are embryologic stem cell transcription factors that bind an enhancer region on the nestin gene, and they are preferentially co-expressed in metastatic melanomas when compared with nevi or primary melanomas
Antioxidants can inhibit the expression of tumor suppressor proteins p53, a highly mutated transcription factor in cancer, and phosphatase and tensin homolog (PTEN), p21, and p27 (Singh et al
183 The Leu allele of this variant induces relaxation of glucokinase inhibition, resulting in heightened glucose phosphorylation
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Consequently, inhibiting ACSL4 expression represents an important direction in ferroptosis research (43)