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TRANSCEND-T2D-1's 5.1% is the lowest yet likely reflecting the diabetes-specific population and shorter trial duration
PMID: 35389500, PMCID: PMC8990329, DOI: 10.1001/jamanetworkopen.2022.6385
The proposed mechanism for this adverse outcome involves a paradoxical effect where GLP-1RA-induced metabolic shifts cause transient retinal hypoxia, triggering the upregulation of pro-angiogenic chemokines like CXCL12 [112]
The peptide has been studied for injectable or implantable sustained release depot systems for the targeted or localized delivery of drugs
Liraglutide Attenuates Nonalcoholic Fatty Liver Disease through Adjusting Lipid Metabolism via SHP1/AMPK Signaling Pathway
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