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In rare, tragic cases, severe deficiency has led to major neurological complications, especially when ignored

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Generation of T4 knockouts using TALEN We used TALENs to disrupt the T4 gene, designing a spacer nearby the ATG start codon of T4 to generate a frame shift mutation and loss of T4 function

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They discovered that the drugs blocked the animals body from absorbing compounds called amines which include serotonin, a chemical that carries messages between nerve cells in the brain

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