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Although AtGrxS15 catalysis was less efficient than for the dithiol glutaredoxin AtGrxC1, the oxidation of roGFP2 clearly depended on the concentration of AtGrxS15

Disclosures Ildiko Lingvay has performed consultancy for AstraZeneca, Boehringer Ingelheim Pharmaceuticals, Inc., Eli Lilly and Company, Intarcia Therapeutics, Janssen Pharmaceuticals, Inc., MannKind Corporation, Novo Nordisk A/S, Sanofi, TARGET PharmaSolutions and Valeritas, Inc

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Higher doses increase the risk of diarrhoea and other adverse effects