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Clinical B12 levels are achieved quickly, and the effects are more noticeable and predictable than with oral supplementation, where individual absorption rates vary widely

[3] Those taking high-dose oral supplements without medical supervision also face increased risk

For severe deficiencies, especially those with neurological symptoms, a full resolution of symptoms might take several weeks or even months of consistent treatment

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As we age, our bodies produce less stomach acid and other compounds that help to absorb B vitamins