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It was originally designed to treat type 2 diabetes but has gained widespread use for weight loss

Semaglutide ameliorates ovariectomy-induced osteoporosis and increases the expression of -catenin, leading to increased bone formation and halted receptor activator of nuclear factor kappa- ligand (RANKLs) activation

These are signs of degradation or contamination

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Dynamic light scattering (DLS) Lyophilized Syn WT , Syn S129E , and Syn 1103 proteins were freshly reconstituted in an assay buffer containing 20 mM Tris-HCl pH8.0 and 150 mM NaCl