The main cause of gum disease is plaque, a sticky film of bacteria that forms on teeth when you eat sugary or starchy foods and don't brush and floss well
doi: 10.3389/fnins.2021.700297 Received 25 April 2021 Accepted 30 June 2021 Published 10 August 2021 Volume 15 - 2021 Edited by Anglica Zepeda, Universidad Nacional Autnoma de Mxico, Mexico Reviewed by Ruth Marie Beckervordersandforth, Friedrich-Alexander-University Erlangen-Nrnberg, Germany
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Downregulation of the receptor also occurs through dephosphorylation by several protein tyrosine phosphatases and protein inhibitor of activated STATs (PIAS)
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Gradual escalation reduced gastrointestinal side effects versus starting at a higher dose