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These SGLT2 inhibitors may also help protect mitochondrial function and tubular cell metabolism (Nespoux and Vallon, 2020)

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Combination therapy significantly and additively improved all these liver defects

Additional file Additional file 1: Table S1

The recognition of LeschNyhan syndrome as an inborn error of purine metabolism

Supplementary material The Supplementary Material for this article can be found online at: Abbreviations Angptl4 Angiopoietin-Like 4 bLPL bovine LPL BSA Bovine Serum Albumin CVD cardiovascular disease CXN calnexin EL endothelial lipase ER endoplasmic reticulum fAngptl4 full-length Angptl4 FFA free fatty acids GPIHBP1 glycosylphosphatidylinositol-anchored high-density lipoproteinbinding protein 1 HDX-MS Hydrogen Deuterium Exchange Mass Spectrometry HL hepatic lipase HR heparin release HTG hypertriglyceridemia KRP Krebs Ringer Phosphate LMF1 lipase maturation factor LPL lipoprotein lipase nAngptl4 N-terminal domain Angptl4 PC proprotein convertase PHP post-heparin plasma SorLA sortilin-related receptor with type-A repeats TG triglyceride TRL TG-rich lipoproteins VLDL very-low density lipoproteins