oral tirzepatide vs oral semaglutide Pill: FDA-Approved Options Comparing Oral and Injectable Forms

Slows Digestion : Slows digestion for longer-lasting satiety

JAMA 313:2456

Hyperinsulinism/hyperammonemia syndrome in children with regulatory mutations in the inhibitory guanosine triphosphate-binding domain of glutamate dehydrogenase

Note: an older GLP-1, liraglutide (Saxenda) , is also approved for weight management but is being discontinued as newer options take over

To put that in perspective, the approved GLP-1 drugs achieved less weight loss in longer timeframes: for example, semaglutide (Wegovy) averages about 15% weight loss over ~16 months, and tirzepatide (Zepbound) achieved around 22.5% at 72 weeks in trials

Strength training, such as lifting weights or using resistance bands, builds lean muscle