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Dysfunction of this transport mechanism leads to abnormal copper accumulations in the liver, brain, eyes, and other organs, with consequent major and variably expressed hepatic, neurologic, and psychiatric disturbances

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However, Cu-Al alloy coatings exhibited significantly reduced copper ion release compared to the 100 at.% Cu coating

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However, this evidence cannot be directly applied to the phentermine-tirzepatide combination due to different pharmacological profiles

10.1016/J.BIOPHA.2021.111921 29 Diaz-MoralesN.Rovira-LlopisS.BaulsC.Lopez-DomenechS.Escribano-LopezI.VesesS.et al (2017)