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Tesamorelin is an FDA-approved prescription drug (brand name Egrifta), cleared in 2010 on the strength of multiple Phase 3 double-blind, placebo-controlled randomized trials for a specific, narrow indication: reducing excess abdominal fat in people with HIV-associated lipodystrophy

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Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane

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This system comprises the enzyme plasmin, which dissolves fibrin (fibrinolysis) through protein cleavage