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Accordingly, studies using psychophysical testing, patient-reported food pleasure, cue-reactivity paradigms, and adverse-event reporting should not be interpreted as equivalent evidence for the same biological construct (Table 1)

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Key insight: Retatrutides glucagon-mediated increase in energy expenditure means the body is simultaneously eating less AND burning more a combination that may explain the superior efficacy signal seen in early trials

doi:10.1016/S0140-6736(14)61682-2

28 WangH.WangL.Erdjument-BromageH.VidalM.TempstP.JonesR

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