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The mammalian Hippo pathway can be simplified as an MST1/2-LATS1/2 kinases-mediated phosphorylation cascade that controls subcellular localization of YAP/TAZ, the major downstream transcriptional coactivators that may enter the nucleus and bind TEAD family of transcriptional factors to induce target genes expression 22,24,25

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10.1016/j.cmpb.2025.108658 Comput Methods Programs Biomed