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Researchers also noted that participants who discontinued treatment after a sustained period began to regain weight during follow-up, reinforcing that Mounjaro works best as part of an ongoing, medically guided treatment plan rather than a short-term course

This includes enhanced insulin secretion in response to elevated blood glucose, suppression of glucagon release , and delayed gastric emptying

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Resources Honda, Yasushi, et al

Tirzepatide (Mounjaro / Zepbound) a weekly injectable that acts on both GLP-1 and GIP receptors, offering added benefits for glucose and fat metabolism

Phosphorylation of GluA1 promotes the recruitment of AMPARs to the membrane, enhances excitatory postsynaptic potentials, and consequently inhibits feeding behavior [10]