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They should be avoided in patients with gastroparesis and in those with severe renal impairment, defined as creatinine clearance less than 30 mL per minute per 1.73 m 2 (0.50 mL per second per m 2 )

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Nestin, a class VI intermediate filament protein, is predominantly expressed in undifferentiated neural progenitor cells within neurogenic regions like the subgranular zone of the hippocampus