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Pickart and colleagues used gene-signature databases to report that GHK modulates the expression of a large number of human genes including DNA-repair, antioxidant, and anti-inflammatory pathways shifting expression toward a healthier pattern

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The researchers utilized the Achilles functional index (AFI), myeloperoxidase activity, histological inflammatory cell influx, and vascular index as potential markers

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35 This analysis helps identify specific movement patterns that increase the risk of ACL injury, such as excessive knee valgus (inward collapse of the knee) or improper landing mechanics