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While new indications for conditions like heart disease may broaden access, high costs are causing many employers and pharmacy benefit managers to add restrictions

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however, the clinical relevance of these effects in adolescents has yet to be established

Over five years, non-GLP-1 spending increases by $6,800, or 30 percent of the amount spent on GLP-1s

Furthermore, GLP-1R activation has been reported to suppress GABA_A receptor-mediated currents in retinal ganglion cells, indicating a broader role in modulating inhibitory neurotransmission [33]

A DESeq DataSet object was created from the count matrix and metadata