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The most definitive indicator is consistent on-target toxicity at therapeutically relevant exposure levels

[4] The same analysis modelled cardiometabolic markers trending back toward baseline, with projected return close to baseline by about 1.4 years after stopping

Overall it seems like a very promising alternative offering similar results to Wegovy with a similar side effect profile to current GLP-1 RA weight medications, said Garcia-Webb

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The RNA-dependent condensation of G3BP is a major driver of SG assembly, and G3BP-interacting partners can influence SG dynamics by altering the SG condensation threshold ( 14 16 )