2.3 Search strategy The literature was systematically searched for English articles published up to June 6, 2022 from the following databases which were PubMed, Embase, Web of Science and Cochrane Library
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156603) to block nonspecific antibody staining
Top-line trial details - ~1,700 adults with type 2 diabetes - Head-to-head vs oral semaglutide 7 mg and 14 mg - Doses tested: orforglipron 12 mg and 36 mg Primary endpoint: A1C reduction - Orforglipron 36 mg: 2.2% A1C - Oral semaglutide 14 mg: 1.4% A1C Weight loss - Orforglipron 36 mg: 19.7 lbs (9.2%) - Oral semaglutide 14 mg: 11.0 lbs (5.3%) - Roughly 7.3% greater relative weight loss Importantly, orforglipron did have HIGHER Adverse Events like nausea, diarrhea, vomiting, dyspepsia, decreased appetite, leading to more people dropping off Discontinuation due to AEs: - Orforglipron 36 mg: 9.7% - Oral semaglutide 14 mg: 4.9% Orforglipron Beats Semaglutide in Head-to-Head Trial for Diabetes, Weight Loss Eli Lilly just posted head-to-head data showing its oral GLP-1, orforglipron, beat oral semaglutide across blood sugar and weight loss in a 52-week Phase 3 trial
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