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The extensive SURPASS clinical trials, encompassing eight completed studies, have evaluated tirzepatide as both monotherapy and in combination with other treatments (4)
Insulin therapy, weight gain and prognosis
Serendipity also plays a powerful role
Kramer CM, Borlaug BA, Zile MR, Ruff D, DiMaria JM, Menon V, Ou Y, Zarante AM, Hurt KC, Murakami M, Packer M, SUMMIT Trial Study Group
Active weight loss phase (months 2-9, therapeutic dose): This is where appetite suppression is strongest and the muscle-preservation stakes are highest
10.1016/S0140-6736(15)00803-X 3 ArvanitakisK.KoufakisT.KotsaK.GermanidisG
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